Abraham Olufemi Asuku
Metals are crucial for normal neuronal function, supporting enzymatic activity, neurotransmission, and cellular homeostasis, while also causing imbalances or excessive accumulation in the brain to become pathogenic. Metal dysregulation disrupts key cellular processes, including mitochondrial function, redox balance, and protein folding, ultimately leading to neuronal injury. Various therapeutic and preventive strategies may provide further comprehension of disease-specific mechanisms and provide new improvements to clinical interventions. Further research on neurotoxic metals as critical environmental and biological factors that act through interconnected molecular pathways to drive progressive neurodegeneration, may offer insights that are vital for understanding disease mechanisms and developing targeted therapies. Implications of Neurotoxic Metals on Neurodegenerative Diseases provides a comprehensive and mechanistic overview of how exposure to toxic metals contributes to the onset and progression of neurodegenerative diseases. It integrates evidence from molecular biology, toxicology, neuroscience, and epidemiology to explain how both essential metals and non-essential toxic metals influence brain health. This book covers topics such as neuroscience, biomarkers, and public health, and is a useful resource for medical and healthcare professionals, engineers, policymakers, academicians, researchers, and scientists.
